Liver enzyme 6 times higher than it should be.

[Biddy007]

Hi Ladies,

I've just had my meeting with my oncologist and we discussed my blood work. He has taken me off the Palbociclib for a month to see if my liver readings will come down.

The last time there were so high was in the beginning when I was also taking antidepressants and and artificial thyroxine. This cocktail of drugs did not mix well in my liver.

Once I had dropped the the antidepressant and and change the thyroxine to a bovine sourced natural drug things settle down. This time I can't see what what I can do to get the readings down.

I don't smoke or drink alcohol. The thought has crossed my mind that I'm becoming allergic to the palbociclib and perhaps not able to tolerate it any more. I have dropped down to 75 mg but even this seems too much for my body. I have been NED for the last three scans so I don't know if the palbociclib is doing more damage than good to my body.

Just wondering if anyone else has had this reaction to the drug.

[Hidden]

Hi Biddy007...

Hmmm....I'm sorry you're dealing with this issue (but glad that you've had NED for so long!!).

Are you saying that you had the issue kind of before you had been on Palbo (or since not long after), which you attributed to your meds, and now without those meds, you have it again? And you're wondering if now it's due to Palbo?

If this is the case, I'm wondering if you've seen a specialist to possibly find a reason unrelated to your medications? I'm assuming you've not been a Tylenol user, that one's obvious, but do you know that you don't have some other source of liver disease?

I'd really hate to see you possibly compromise the cancer treatment if by any chance the liver issue is caused by something else...

Best of luck with it...

Lynn

[hdhonda]

Gosh, Biddy, I don't have any suggestions or answers. It sounds like your doctor is using the process of elimination in hopes of finding the cause. It seems like a sound plan to me. Hopefully, he will find the cause soon. Blessings, Hannah

[Red71]

Taking you off the Ibrance should prove whether the Ibrance is causing your high liver blood work. If the results don’t change, then maybe a scan is in order. You also should scour your mind for anything that has changed in the last month or two...something that you are eating that you haven’t eaten previously, vitamins from a different company or brand, more pain medication, something that is natural and supposedly benign? Sometimes we make changes but don’t really think about it because they are so minuscule!

The fact that you have been NED for as long as you have should tell you that the Ibrance is worked for its primary purpose and has been good for you. The other thing that just occurred to me is that they should just redo your blood work. Sometimes labs do make mistakes. It happened with my husband who had a much higher fasting blood sugar than ever previously. He is compulsive about keeping it down. After his doc said something about his last three patients having high blood sugar, they retested. It turned out that the lab had not calibrated their machine correctly and all three blood sugars were normal the next time.

Good luck with figuring out what is going on. Hugs.

Elaine

[PLASEM]

You should suggest PET scan unless You had one recently to see if your liver is ok or not God Bless you