Biotin and tumor markers: My tumor... - SHARE Metastatic ...

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Biotin and tumor markers

My tumor markers 27.29 went up 25 points last month. Coincidentally, I had started taking a skin, hair and nail supplement with high doses of biotin and other vitamins and minerals a couple months before the blood test. I have heard that high doses of biotin can interfere with blood test results. Has anyone else had this experience?

I’m having a PET scan next week to determine if there have been new metastases.

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I take Ribociblib and Letrozole. Because of my thinning hair, I asked my onc about taking Biotin and he said no because it interferes with Ribociclib (which is the same as Ibrance)

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I am taking Letrozole and Xjeva. I’ll ask my onc if biotin interferes with those meds. It is possible that the biotin interferes with my lab tests.

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Oh my. I am 27.29 and started biotin last month. My numbers went up 40 points. I asked my oncologist if it was ok and he said yes. After reading this I will stop taking the biotin.

I will message him regarding this Monday. I also want to go on metformin. It is supposed to reduce your sugar. I read this in Starving Cancer book.

I also take vitamins, aspirin, and a statin.

I am seeing my oncologist March 18th for my faslodex shots and I will discuss this with him.

I am having another PET scan March 20th.

I am glad to have a 27.29 buddy.

I live in Rochester NY.

I went to Sloan Kettering in NYC for a second opinion when I was diagnosed.

Reenie. My email is Rbethgold@yahoo.com

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Please watch out taking metformin. It tore up my digestive system awful. Had to have my gallbladder removed months later. I was then put on glimiperide and it was easier on the stomach.

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May I ask what a 27 .29 is?

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It’s my tumor type.

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CA 27.29 is an antigen, a specific type of protein present on the surface of breast cancer cells. These breast cancer cells can shed copies of the CA 27.29 protein into the bloodstream. When the levels rise, it COULD mean that your cancer is progressing. But other benign factors may cause elevated 27.29 markers as well.

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I’m in Florida and they do CEA, and CA 15-3. Why are there different ones? I’m MBC ER+ PR+ HER2-

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Hi

I’m in uk and they don’t do the 27.29 test here

They test CEA and CA 125(?)

Barb xx

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My oncologist checked re biotin supplements and it does interfere with markers

Mine went up when I took it..I’ve obviously stopped but just worried if markers keep going up it’s due to progression

Barb xx

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I started taking biotin about 4 months ago - it did not seem to change my levels.

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I've never looked into biotin, but I have learned alot about tumor markers. Things besides cancer progression can cause them to rise. A change of 25 points doesn't really mean much as TMs are "not precise" but since they are numbers, we tend to think they are. Also, a change between two successive TMs doesn't mean alot--it's an upward change over time. And they are not accurate for all of us. Many oncs don't use them at all for that reason, or use them only for their patients with bone mets since those can be hard to monitor with scans as healing bones and progressing mets can look alot alike. Onc's do not change treatment plans based only on TMs. They pay more attention to how we report feeling. Scans are second and TMs a very distant third.

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I’ve never heard that but good to know as I just started taking them myself

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Maybe this is why so many oncologists do not do tumor markers! They are not reliable and too frightening. We have enough crazy with this disease and maintaining our sanity!

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My oncologist had supplied me with a memo from our local lab awhile ago that alerted to biotin in higher dosages has a potential to interfere with certain lab results. Here's the take away message:

Biotin, when taken in doses >1 mg per day, may positively or negatively interfere with many of the laboratory tests offered by labs, including βhCG and high sensitivity Cardiac Troponin T. Biotin interference can result in falsely low results for serum βhCG and high sensitivity Cardiac Troponin T leading to misdiagnosis and mistreatment. Biotin also affects urine pregnancy testing and many cancer markers.

Action Required: Request that all patients discontinue Biotin supplementation for 48 hours prior to specimen collection for laboratory tests.

In addition here's another link from the FDA that mentions tumor markers as well.

womenshealthct.com/your-hea...

Hope that helps some.

Sandra

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Thank you! Super helpful. I wondered how long one needed to stop biotin before markers are drawn. I think it is also important to underscore that biotin interferes with the lab tests but does not promote the progression of cancer itself. I have seen some previous posts where some may have interpreted the effect of biotin differently.

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Biotin absolutely does interfere with blood work you should not take it a certain number of hours before your lab work. Ask your lab for details.

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Unfortunately, it was not the biotin that caused my elevated tumor markers. PET scan showed mets to the liver. I have a consultation with a radiology oncologist on Monday to have the cyberknife procedure on the liver tumor. It may take a couple of sessions to completely zap it.

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Sorry to hear this but sounds like your oncologist is on top of it and has a plan of attack which is so important. The liver is very resilient and many people have had cyberknife done with great success. Good luck.

Sandra

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I have been taking biotin for over a year and haven’t noticed a change in my numbers to coincide with starting the biotin.

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