By this I mean that a new prescripton can bring wonderful initial relief, yet over time the body becomes more tolerant and the problem is back to square one.
In my case I was diagnosed a few years ago and initially presribed Ropinirole 1mg, which worked well to start with, then the symptoms returned progressively so that over a period of time I was taking 3mg and still suffering eventually.
At my last appointment with the Neurosurgeon last March he introduced me to the wonders of the Neuropatch, and I thought that this was the best thing since sliced bread (and have posted comments to this effect on here). However, since Christmas my symptoms have returned with a vengeance (I'm typing this at 8.45am, having had 1 hours' sleep, after which I awoke with twitching arms). I have to say though that the patches are very effecive in the evenings.
My GP has added 300mg Gabapentin and 2x5mg Nitrazepam to my prescription, and again initially they had a positive effect on the symptoms, but no longer.
In summary, I find that each incremental increase in medication(s) has, maybe, a 9-month shelf life.
Fortunately I'm retired, so the effect of all of this is not so devastating as it is for someone who has to hold down a job, and I'm also aware that this 'disease' is progressive with age, but i'd be interested to hear comments from those with similar experience. And good luck and best wishes to you younger sufferers.