The History of Dopamine in Restless L... - Restless Legs Syn...
The History of Dopamine in Restless Leg Syndrome - Brian Koo, MD, Yale Sleep Medicine Grand Rounds - January 15, 2025
Nice - I had to watch it on YouTube - click the YouTube link. No time stamps, so you need to watch in total or pull up the status bar to "search" the video. Apparently Sleep Medicine Grand Rounds has been around since 1996 offering lectures at various universities including Harvard, Yale and many others. From Harvard... "Sleep Grand Rounds is a monthly research seminar program that has been conducted each academic year since September 1996, incorporating faculty presentations on basic and clinical sleep research."
Curious enough - consider this - also from Harvard: "The 2023 - 2024 Sleep Grand Rounds Program has received support in the form of an educational grant from the following companies: Avadel Pharmaceuticals, Harmony Biosciences and Takeda.
youtu.be/KWKH286hheQ?si=B6G... link didn't work. But you can search directly on YouTube
It's a great video. Apparently RLS brains have too much dopamine!
One thing Dr Koo stresses is that gabapentin enacarbil is better than gabapentin or pregabalin. BUT they put gabapentin first in the new AASM guidance because of the cost factors in the USA.
Hopefully everyone will be able to view this video.
Interesting, but unfortunately gabapentin enacarbil is not available in Australia.
Good morning Joolsg,
Just watched Dr Koo's video. I found it quite interesting and i am sure useful to people just starting out with RLS treatment.
I wondered whether you could guide me to a paper or video on my specific problem namely the mechanics of buprenorphine side effects?
Kind regards
Davchar23
ncbi.nlm.nih.gov/books/NBK4...
There aren't many studies on Buprenorphine for RLS. But there are studies for opioid use.
frontiersin.org/journals/ph...
Another article. Tolerance doesn't tend to happen when opioids are used for RLS rather than pain.
Davchar, there aren’t many studies. And few really address side effects, as most studies aim to assess effectiveness. Main conclusions are that there are few side effects, generally fewer than with other opioids. But in fact not many studies have been done thus evidence is flimsy.
