Dipyridamole update.

[WideBody]

I recently had to stop taking Dipyridamole prior to surgery. Day one wasn’t an issue, I slept great. Day two was a huge reminder of how bad RLas can be. Day three I am just vibrating.

Now it could be the stress from the surgery but my RLS is through the roof and it is only 8:30 am. I can sleep for only 10 minutes at a time. I talked to the doctors and Dipyridamole is back on the menu, soon I hope.

[Amrob]

That's interesting to hear thanks WideBody.

Did you take any other meds before or after surgery? I'm wondering whether there is another factor at play or whether the change might be solely attributable to the efficacy of dipyridamole.

[BAK524]

Wow thanks for sharing this. I am using dipyridomole with much success, and I have recently been wondering what would happen if I suddenly stopped taking it. Keep us posted on your recovery.

[BAK524]

Wide Body, did your RLS come under control when you went back on dipyridomole? Do you experience day time symptoms, and does the dipyridomole help? What's your take on your situation?

[WideBody in reply to BAK524]

I am back on Dipyridamole absolutely! I take 225mg a night. I can even skip a night. Skipping two nights is rough. I actually skipped last night, because I was taking Ibuprofen and Tylenol per Doctors orders. I slept great.

Dipyridamole is by far the most effective medication and more importantly Dipyridamole has the least side effects for me. I used to get headaches, that doesn't happen anymore.

Good Luck, I intend to stick with the Dipyridamole.

I do still have to watch my iron. Boy did it plummet after surgery! So I am back on Liquid Ferrous Sulfate for a bottle, then back to Ferro Chel (Ferrous Bisglysinate).

[BAK524 in reply to WideBody]

Thanks for the update. I am having success with dipyridomole as well. When I do experience some breakthrough PLM, it's not as intense, and I seem to be able to go back to sleep. I'm a bit surprised others are not trying this medication...

[WideBody in reply to BAK524]

Preach it girl! Of everything, and I have tried everything except low dose opioids, Dipyridamole has the least side effects by far. I can even skip a night, not that I do, but it happens.

I do think Dipyridamole helps certain people more than others. Secondary RLS caused by an iron deficiency, creates a drop in inter cellular adenosine in the brain. Dipyridamole is an ENT1/ENT2 inhibitor. It blocks the ENT2 receptor, in doing so it increases inter cellular adenosine. At least that is how I understand it.

You explain it beautifully, when PLM happens it is not as intense, I can go back to sleep easier.

[TeddiJ]

Hi, WB, and sorry to hear of the surgery. I hope it was productive and you are healing well. Thanks for this info and it is prompting me to try Dipy again. I have a supply here, even, but didn't like it the first time around. I never did get to a good dosage though, so I need to find out if it does or does not work at 200 to 300. Thanks and feel better soon...