Anyone have experience on how psilocybin may effect RLS

[ziggypiggy]

I'm looking to give psilocybin a try for my treatment resistant depression. My big concern is that it regulates seretonin. I've always had a bad reaction to any drug which uses seretonin as it's mechanism of action. Makes my legs go crazy. So I suspect this may as well. The evidence on psilocybin is that the antidepressant effect can last months. Yet, i would assume if I had any increase in RLS it would only last the 6 to 8 hours of the trip itself. Anyone know anything?

Weighing the whole risk/reward thing.

[Hidden]

I've no experience of psilocybin, but logically if the effect only lasts a few hours then any effect it has on your RLS will be temporary.

The potential anti-depressive effects of psilocybin are more psychological than physiological so please be careful. I hope you're taking it under supervision.

From my experience of LSD, decades ago, it's potentially harmful in the wrong circumstances.

[DicCarlson]

There is lots of info out there on the benefits of micro-dosing Psilocybin - here's a clinic that actually offers it. It also seems that Johns Hopkins University (also a leading research for RLS) is a leading research hospital for low dose Psilocybin research...

bewellct.com/psilocybin-the...

hopkinspsychedelic.org/

[RCHD]

If anyone has any experience I’d love to hear too... I’ve heard it can help and heard it can also increase.

[Amrob]

I can't comment on psilocybin but have been reading about Repetitive Transcranial Magnetic Stimulation (RTMS) for RLS / PLMD. Apparently it can be effective for treatment resistant depression. Possibly something to keep up your sleeve.

[ziggypiggy in reply to Amrob]

Yeah. I tried a thirty six course treatment series of TMS. No luck with the depression. Didn't effect my RLS either way, although I was kinda hoping some side benefit. Also have done ECT. Same results. The Ketamine nasal spray worked for a little bit but then petered out. So yeah, I'm turning over all the rocks. It's either fight or give up. Still fighting.

[Amrob in reply to ziggypiggy]

Sorry to hear that the TMS didn't work for you. Or ECT. Hopefully you find something that does work real soon! I like your 'still fighting' attitude 😀