I have suffered with RLS for at least 30 years. After a long struggle, I am on Myrapex and hardly ever have RLS anymore. However, sometimes I still get it. For many years, I have suspected that aspartame may cause my RLS. I recently spoke to my daughter who is 38 and has had glaucoma since she was 11. She told me that aspartame affects her vision so she no longer can tolerate it. That sparked my thinking (before my Myrapex) that aspartame affected me as well. I did little experiments with the amount of aspartame I consumed through the years and it always turned out that the more aspartame I had, the more my RLS acted up. Oh well, that's my theory!