It is such a crazy dance we do with our RLS drugs. I’ve had it for many many years...before doctors were able to diagnose it. Mirapex was the first rx I used. It worked for quite a while but the side effects caught up with me. I had sudden onset of extreme sleepiness while driving. Crossed the road into a ditch and couldn’t be seen from the road. In the hospital they abruptly took me off mirapax and started me on a gaba... after being on that for a few months I got so depressed and anxious that I couldn’t even go grocery shopping. So was prescribed antidepressant and anti anxiety. Those drugs messed me up so much that I ended up leaving a 36 year marriage. There were, of course, underlying problems but I lost the ability to cope. In the last few years I have worked out a system where I take prami in the middle to late afternoon and if I have breakthrough symptoms I take hydrocodone. I have managed to make this work until recently when I have more breakthrough symptoms and wake up in the wee hours of the morning with pain. I guess what I’m trying to say is that it takes some experimenting. Side effects can be life changing.