Am currently on acute psych ward for depression and anxiety, closely connected with the terrible effects rls has had, augmentation on pramipexole - reducing, down to 1 tablet tomorrow night from 4 some weeks ago. Doctors here refusing to get involved in addressing rls, saying it is not their field and I must wait for a neurologist's opinion....however I so far have no access to a neurologist! I am however being started on duloxetine tomorrow, after my current antidepressants have been withdrawn, as something used to treat depression and diabetic neuropathy, as the best they can offer. I am allowed paracetamol and codeine prn, although I try hard to save the codeine for times when I am really in extremis, like 3 am. I use CBD Brothers balm massaged into my feet and legs before bed and periodically during the night. Anyone have any experience of duloxetine? I am terrified of starting anything that might make my rls worse!