I deal with depression and anxiety and have for many years. I have been on Zoloft and other antidepressants for over a decade. A couple of months ago, my doctor wanted to increase my dose. Pharmacist recommended I switch from taking it in the morning to taking it at night before bed. The recommendation was due to my chronic insomnia. The first night taking the increased dose, my RLS increased 10 fold! I didn't put 2 and 2 together for a few days and I'm doing some online research. APPARENTLY, some people don't get sleepy and react completely differently to these meds and other meds. (I already know I can't take nighttime cold meds as it makes me jumpy and wide awake. Complete opposite effect of nighttime meds.
Long story short, I STOPPED THE ZOLOFT IMMEDIATELY! Yes, I told my doctor after and she was onboard with that. Within a few days of stopping it, my RLS symptoms all but disappeared! I DO find that about a week to 2 weeks leading into my period, my legs start acting up. I believe that is still due to low iron levels though.
I wanted to share my experiences as I had to figure out the connection on my own. My doctor and all doctors I've dealt with didn't have a clue about the connection to the RLS and I had been going and complaining... in tears due to lack of sleep, for YEARS! I don't trust MD's. We have to be our own doctors and own advocates.
Good Luck everyone!