Coming off Pramipexole

Hi! I am trying to come off Pramipexole because of augmentation. I am down to one 0.088mg tablet per day now. My question is, when I get the dopamine out of my system, will my rls revert to how it was before I started taking the medication i.e. Not nearly as severe? Also how long does it take to get this horrible drug out of your system? I wish I had never started taking this drug. Before I did, my rls was an irritation, but certainly not life changing, as it has now become!! Luckily,I have found a sympathetic, and informed GP who is now helping me, and will think twice about putting anyone else on this medication! It has made my life a nightmarešŸ˜¢šŸ˜¢

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  • Sheelag, please put the following names into the search box here and read their stories about getting off the DAs: Mark370, Bkc1777 and bganim1947. Or tap on my name and read my posts. I believe that the first substance everyone has to try for RLS is ferrous bisglycinate 25mg on an empty stomach before bed. It should work. I'm 2 out of 3 this past week alone. I believe it didn't work for that third person because she has an infection right now and her iron stores are high. Anyways please read their stories.

  • Well done for getting this far. Powerful.

    It's difficult to answer your question as most people transfer to another med without waiting to find out their new rls baseline!

    To complicate matters further , there is a little understood situation called DAWS which is a continuation of bad experiences after DAs .

    I am directing you to a site that relates one persons experience and an extensive discussion on her predicament.

    rxisk.org/sos-dopamine-agon...

    I hope this gives you some information even if it is not very hopeful.

    I came off Prami- but went immediately over to oxycontin (lower back pain) and after about 3 or 4 months of adjustment am now doing well.

    It will be interesting to see how you get on - if you try to find your base level of rls without any medication.

    Don't forget to check out all possible triggers that may seriously affect your recovery.

    Please keep in touch and I wish you all the very best.

  • Have just delved into that site- there are some good suggestions for coping- especially concerning vit B.

    Anyone coming of DAs or indeed on DAs should definitely follow up that link.

    Frightening and fascinating.

  • Hi! Sorry, I should have said. I am actually on OxyContin, and Tramadol if I need it, just to get me off these Pramipexole. I was wondering, if things settle down a bit, after the Dopamine effect wears off.

  • Hi,

    Well done making the decision of coming of prami! It is evil stuff! :)

    I have been taking prami for 8 months and it has been 2 weeks now as I took no medicine route... I have gone cold turkey and did not use any tramadol stuff either.

    Some suggest minimise the dose and get off with the help of codein/tramadol or just give up and go through hell few days :)) How long have you been on prami?

    Since I have found this site I have started eating healthier and trying low foodmap diet and stopped alcohol completely. I am introducing food to my diet slowly to see what triggers my RLS and finding out that some of the no no's in foodmap diet is actually ok with me. So it is a slow journey but I am getting there faster than I thought! :)

    When I gave up prami 2 weeks ago I went to Holland and Barrett and stocked up on some vitamins that people thought might help. I started taking gentle iron, (iron bisglycinate) 20mg. I tell you what, it helped big time! First few days was hell but 4th day I woke up as a new person! I am not sure if prami is out of my system yet (feels it has, but still have a little moods, maybe that's my personality eh? ;) ) as it depends on the dosage and and the length of time you have been on it. I am now using b12, folic acid, calcium, magnesium during a day. But the iron only at bedtime on an empty stomach with orange juice. I tried not to take any of iron last night as tredlight (another lovely person who helped on my journey) takes it only when her rls is bad. She treats iron as it is painkiller. Only to be taken when rls really bad and can't cope. So I tried no iron last night, woke up at 1am with rls, slept on my knees a bit, bent my toes, then it was ok to get back to sleep again! I am not trying to make it look easy to give up prami but that is my experience. Some would says this iron route didn't work for them but in my case IT DID! I have come a long way, and feeling so good for it!

    So go for it, try and see how you get on with it. You could always try to take prami when rls is unbearable as you don't need to take every night.

    In the end of the day everyone is different and they have to do whatever to feel better to cope with life!

    Read through everything on this forum and you will see you gained so much knowledge and knowledge is power! :) Then go to your GP and have a chat for the route you are going to take.

    Good luck,

    And believe in yourself!

    B.

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