Improved symptoms after getting off pramipexole

[Busyleggs77]

I have RLS, usually get it after 6pm for 2-3 hours and sometimes after midnight. So I went on .125 dose of pramipexole for RLS for about a month, it worked but had to go off it because it was giving me racing/pounding heart at night. First couple days RLS was worse, then it has gradually tapered off, and now 2 weeks later I have about 90% less symptoms than I did before I went on the drug! I am really hoping this lasts and I have permanently reduced symptoms.

[Madlegs1]

I hope so as well.

Maybe you have discovered a new algorithm to manage RLS.

Let us know how you progress-- you could be making medical history!

[Busyleggs77 in reply to Madlegs1]

Yeah it feels like I'm dreaming...had this daily for years, also it would always start in one leg and then switch to the other after an hour or two. Now I get it in one leg very mild for 10-15 minutes and it doesn't do the "switch" it just stops and leaves me alone! I am going to wait a couple more weeks and if its still improved I will report it to the M.S. nurse and doc. Could be the dopamine output shifted in my brain, very glad I went off the drug when I did!

[Madlegs1 in reply to Busyleggs77]

What other medications are you on?

Don't want to put a hex on anything, but could be another explanation!💚

[Busyleggs77 in reply to Madlegs1]

Not on any other meds! Not doing anything different other than going off those scary pills 😅

[Madlegs1 in reply to Busyleggs77]

Good for you.

[SueJohnson]

That's great - hope it lasts.

[Joolsg]

Fingers crossed it lasts!

[MrCrow]

I don't know about improved symptoms, but I took pram for about a month and a half and it had no or very minimal effect on my RLS. When I tapered off of it by taking 0.125 for about 7 or 8 and then stop completely, it didn't make a difference in my symptoms at all. Nothing I could notice anyway.

[Busyleggs77 in reply to MrCrow]

So much mystery surrounds rls and also treating it, what works for one person doesn't for another. Have you tried gabapentin or anything else? I hope you find something that works for you 🙂

[Jumpey]

Long may it last!

[Operaqueen]

Hi Busyleggs77 - I must say I hated being on Pramipexole - I didn't have palpitations like you but I didn't like how it made me feel. I had to really gradually come off it - just shaving off parts of the pill every day until I could have reduced the dosage. I came off it about a year ago and now am on gabapentin which I find works well. I am gradually trying to come off that now. I don't have RLS anymore since having an operation on my back that dealt with the pressure my vertebrae was putting on a nerve (sciatic I think).

[Busyleggs77 in reply to Operaqueen]

Thats amazing that they were able to fix your back! Yes now you can get off that drug and enjoy your new relaxed legs 😀 Yeah pramipexole made me feel weird and anxious, I think my body knew it was bad news.