5 HTP and L Tryptophan for withdrawal relief?

Just come across these substances as aids mainly for opiate withdrawal. But wonder if they would have a place in all the withdrawal situations we come across on this site?

If anyone just googles them , a load of sites come up. They seem to be easily available on both sides of the pond.

Looking forward to replies.😎

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  • Sounds interesting. Tryptophan apparently crosses the BBB more easily. Might try it out. Articles hint that too much carbohydrate and not enough protein in diets causes a lot of our modern day problems and tryptophan addresses this.

    Look forward to hearing from anyone who has had good results using them as well.


  • Passionflower is great for reducing/stopping anxiety and helping with sleep. Also read something about it helping with opiate withdrawal symptoms.

  • Everything you wanted to know about Passionflower...


  • Yes, thank you. I have looked it up on some other websites, and I do use it. It is very helpful.

  • If those substances work for withdrawal from dopamine agonists then logic dictates they should work for RLS symptoms in general, no? Go for it Madlegs. I believe those substances are precursors to Melatonin (or related in some way, shape or form) and at least initially (and maybe always) will aggravate the RLS. But in the process of aggravating the symptoms you might end up with more and better dopamine receptors - hence less symptoms of RLS in the long run. Those are probably not substances you want to take at night. The non-RLS world can take those substances at night, just as they do Melatonin, but sadly not the RLS world. I think the 5HTP may be the least sedating one but that is just what I remember from articles I read long ago. A little 5htp and tea at high noon anyone?

  • Just about able to pronounce the long words!😆 - but don't fully understand the conclusions!

    Happy for you to translate. Unless that's what you've already said!😎

  • The confusing article seems to be concluding that melatonin, by night, will worsen the hypokinesia induced in rats. By day, that same melatonin will help those hypokinesia induced rats. Got all that :)

  • A late reply, as I've only discovered this site recently through the EARLS site.

    5-HTP and tryptophan are precursors to serotonin. And melatonin gets formed out of serotonin. Serotonin is important for sleep, and sleep is compromised in many RLS-patients (including me). Not only because of the RLS itself, but - apparently, according to a Johns Hopkins scientific paper - maybe also owing to an excess of glutamate, which has an excitatory function in the brain.

    Melatonin gets broken down by (day)light. And although melatonin is important for your sleeprhythm, it doesn't seem to help with the sleep problems associated with RLS.

    Long story short.

    Maybe more serotonin (through 5HTP and/or tryptophan) may help improve sleep, which in turn may help you deal better with aggravated RLS during withdrawal. How it may affect dopamine and/or the RLS itself, I don't know.

    I know Lauraflora uses them, although not for withdrawal. And I am, currently, while trying to come off ropinirole (and before switching to gabapentin, if needed)

    I would love to really understand the intricated and unfortunately complicated interactions between the different neurotransmitters and the presence and acitivity of their receptors. And - while we're on it - also the influence of various hormones on the part of the RLS-related system. That would be instrumental in effectively targeting the neurotransmiter-associated problems we experience.

    Final words: give it a try, bit watch your body's reaction closely!

    And keep us updated.....

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