Clinical Trials in Ireland.

Hi all. I've been on a thread where the conversation turned to cannabis use to help with the nightmare of RLS/WED and when I told my other, (better), half she pointed me in the direction of a Dublin company which is performing clinical trials with cannabinoids, specifically phytocannabinoids which are derived from the plant itself and not the synthetic ones which cause a lot of problems including seizures and addiction.

Anyway I digress, the trials are by Green Light Pharmaceuticals and they are taking contact details from those interested in participating in cannabinoid trials in Dublin.

I wouldn't normally advocate trials as they have the potential to be very dangerous but using natural cannabis will not kill or harm you the way others have been harmed in drug trials.

Don't know if anyone is interested but it can only help imho. The site is:

greenlightmedicines.com/cli...

Good to see things moving in a positive way for those of us who could potentially benefit from cannabis.

[Madlegs1]

Great news- my fear is having to come off the oxy before going on to anything else- I've been through the whole withdrawal scene with Fentanyl and Prami. Have no wish to revisit that setup again !!!!😠.

Thanks for the heads up.

I'll follow it up when I get back.

[Hidden in reply to Madlegs1]

I'm surprised you were prescribed Fentanyl, not a good drug. Hopefully some of us will get a call for the trials, fingers crossed 🤞

[Madlegs1 in reply to Hidden]

They put me on Fentanyl post op- but left me on it on leaving hospital after six months. Took me another year to finally get clear.

Did I mention the help I got from Matt Finch site!?😆

[Hidden in reply to Madlegs1]

Nasty! Someone dropped the ball big time on that, fair play getting away from it.

I've an interest in addictions so I'll check out the site, thanks.

[Madlegs1 in reply to Hidden]

I found it helpful- if you ignore the sales pitch. There is some solid good advice and links to other .

Withdrawal is the same across the board- whether from drugs or nicotine or alcohol.

[Hidden in reply to Madlegs1]

Took a scan at the site and the withdrawing from heroin at home was a very good article. It looks like a very useful resource for addictions.

There's a bit of a difference in withdrawals insomuch as I can stop cold turkey with some drugs, (cannabis, opioids and nicotine) with discomfort yes, (I went cold turkey on Tramadol after several years so I know the mess that can be - no preparation just thick wit ), but cold turkey on others can kill, (alcohol and benzos in particular).

I'm a firm believer that all addictions are basically the same, developing and being reinforced through dopamine and glutamate and after the drug is out of the system a variety of techniques can be employed right across the spectrum be it substance or behavioural in nature.

I think one of the hardest drugs to stop and stay away form is nicotine, (it is easier to continue to use without the pressures to stop that heroin, alcohol, etc normally carry).

See what you've started thanks for the link btw,

[Madlegs1 in reply to Hidden]

You're welcome!😆

[Jumpey]

Thanks for posting this Raffs. I can't take part in the trials because I don't live in Ireland but I am very interested in the results. I have been taking CBD oil/capsules for about 6 weeks now with some success. Although it does not eliminate the symptoms entirely it facilitates a functional amount of sleep and I feel much better.x

[Hidden in reply to Jumpey]

Glad to hear you are getting relief. IF you can, try and source full cannabinoid oil it will work better although is illegal in most areas.

[Jumpey in reply to Hidden]

I get mine from CBD Brothers who came recommended by a friend.Any suggestions for where to get what you are suggesting?x

[Hidden in reply to Jumpey]

Wish I knew Jumpy, I'd be using it!!

You can make it if you get your own cannabis, it takes a but its not that difficult if you are careful. There are lots of videos on-line.

[involuntarydancer]

Thanks for that, Raff. I have signed up as a result. I was also intending to write to the minister for health about the forthcoming cannabis bill. My understanding is that it proposes to contain a specific list of diseases for which cannabis can be prescribed and currently RLS/WED is not on it.

[Hidden in reply to involuntarydancer]

The bill seeks to legalise and regulate cannabis products for those suffering serious illnesses like cancer, multiple sclerosis and fibromyalgia, as well as people who live with chronic pain. The INDEPENDENT.

However that is from a newspaper and not likely to be overly accurate, as far as I am aware in the south they are looking it for MS, cancer and epilepsy.

In the north Sinn Féin has said they will look for medicinal cannabis but God knows the DUP will likely block it.

I do hope that it is legalised for pain, insomnia, RLS/WED, cancer, epilepsey, anxiety, depression, poor appetite and the many many other conditions it is known to help.

Hope you get called involuntarydancer, but just after me

[involuntarydancer]

Just looked at the department of health website and speed-read through the report they are basing their legislation on and it doesn't look good. It is recommended for three categories only: severe refractory epilepsy, severe nausea associated with chemotherapy which has not responded to conventional anti-emetics and spasticity associated with MS. NOTHING else. Not even Parkinsons. The report states 'there may be some effectiveness in Parkinsons disease, sleep disorders and post-traumatic sleep disorders but further clinical research is required to characterise these findings.' It is seemingly much more concerned about the link between adult psychosis and teenage cannabis abuse and the 1.2% increase in cannabis abuse by teenagers in US states where it has been legalised for medical use. Apparently anecdotally teenagers state that they gain access to cannabis using a legitimately prescribed supply to a family or household member. This anecdotal evidence is given a lot more credence than any concerning the help cannabis has afforded in treating medical conditions.

[Hidden in reply to involuntarydancer]

Thanks, I thought that was the case, you can never trust a newspaper ime.

Its a start but not great for those of us who would benefit. There is a plethora of research both empirical and anecdotal of the efficacy of cannabis for pain, insomnia, etc. Its very frustrating that with life limiting conditions such as ours aren't deemed severe enough for cannabis yet we can take more dangerous and addictive drugs. Look at anti depressants, some antibiotics and the dopamine agonists and all can cause hallucinations and other thought disorders.

Cannabis is very unlikely to cause psychosis in healthy adults and the research on adolescents and cannabis isn't conclusive. Many adult cannabis users who develop psychosis have been self medicating their poor mental health. Reefer madness remains

[involuntarydancer]

Even the DUP could hardly reduce the availability more ...

[involuntarydancer]

I am not sorry that sources close to me have advanced their plan to orchestrate a more direct access to a supply which those sources can oversee from seed to ... sleep.

[involuntarydancer]

Incidentally full CBD oil is legal and readily available to buy - at hefty prices - here in Dublin. Is that the cannabinoid oil you refer to earlier, Raff?

[Hidden in reply to involuntarydancer]

I tried CBD only oil, (from CBDBrothers on Amazon) with very little success. I've also had the full cannabis oil that worked a treat.

There are 3 types of oil available and from best to worst:

1) Proper cannabis oil made containing ALL the cannabinoids, (thought to be anywhere form 85 - 100+). (Illegal in Ireland)

2) CBD oil made from cannabis. (Legal in Ireland)

3) CBD oil made from industrial hemp and pretty much worthless. (Lrgal in Ireland).

[involuntarydancer]

(2) and (3) were not effective for me either. Cannot get (1) legally. Totally agree with you about the iniquity of illegality of cannabis. Although am grateful that opiates are available. By the logic currently being applied to cannabis, they should probably also be illegal.

[Hidden in reply to involuntarydancer]

Technically opiates are illegal unless you have a letter from your dealer, er, script from your Dr.

I fear the CBD angle is a means to prevent the use of cannabis proper and the healing benefits it has. IF they were so worried about people getting 'high' then Benzo's adn opiates would all be done away with too.

If anyone is interested in what legalisation/decriminalisation of ALL drugs means then look to Portugal - use of ALL drugs has gone down sine the decriminalisation, so has addiction, HIV/AIDS and a whole host of social problems, yet last year the UK brought in more repressive legislation AGAINST the advice of the experts and Ireland's recent law changes to get rid of the head shops/NPS's like the UK's results in the whole thing being underground and in the hands of criminal gangsters, (as opposed to political gangsters).

OK, getting of me soap box.

[Hidden]

Got an email today with the news:

The only conditions we consider worth applying for at this stage are for patients with MS, Epilepsy or who are undergoing Chemotherapy, all of which are aligned with the HPRA review published on 10th February 2017. We will of course assist with other illnesses but feel these have limited chance of success at this stage.

The shower of free state asses made the treatment difficult to get and only for a narrow spectrum of patients, p1ss poor