Or is mother time just doing her dirty deed on our (and everyone's) dopamine receptors? Maybe we RLSers just feel the decline more than your average human who has more and better dopamine receptors to begin with? Isn't it somehow comforting to think that maybe we don't really have a progressive/degenerative disease? And like I said somewhere here before, autopsies of the brains of people claiming to have had RLS during their lifetime do not show disease. Our brains cells are healthy and we actually have plenty of dopamine kicking around. Our brains are just shockingly low on iron and our dopamine receptors (mostly d2 I believe) are pathetic but not "diseased."