My husband who has PSP has Covid now (for the first time). He is in our community hospital for IV fluids and antibiotics. They said Covid medication is arriving today. Recently he has had bad reactions to new medications tried and I’m concerned about these. Have any PSP people had medication for Covid? How was the reaction to this?
Thank you
Hello Rose,
So sorry to hear about the Covid! My husband reacts very badly to certain medications, and thanks to someone from this forum, we figured out that it was medications which are processed in the body using the CYP 3A4 pathway…You can just Google each medication with that and find out if a given medication uses that or not? (Or post the medications, for us to look at the list of the ones he reacts to?)
The most commonly given medication for Covid here, Paxlovid, uses that pathway, so he couldn’t use it, so his neurologist had said in advance that if he gets a bad case of Covid, we’d have to try to get…I can’t quite remember the name, monoclonal antibodies? Or something like that?
My heart goes out to you! So much worrying at a time like this! ❤️
-Lost
Thank you so much, that is really useful!
Hi there, sorry to hear that your dad. My mum has PSP for about 7 years and has no history of drug allergy. She contracted COVID the second time last year (first time was okay she could still cough up and recovered on her own) and was coughing badly with low SpO2. We then took her to the doctor (Emergency department) who prescribed her Paxlovid. Her symptoms greatly improved after 1–2 doses and recovered well after finishing the full course. Thankfully we didn’t need to hospitalise her.
Thank you for your reply Simlez. He is still coughing whether from swallowing problems or Covid I don’t know, he was still testing positive yesterday. I’m not sure what anti viral they gave him but I think this CYP 3A4 pathway may make a difference to how his body uses medication.
Psp hereditary 
PSP 
My dad and PSP
