All, there was a post a several days ago from a caregiver mentioning that their husband was participating in an Abbvie Phase 2 trial of an Anti-Tau medication that, at least anecdotally, was providing relief from some symptoms and possibly slowing the disease progression. My wife is being screened to participate in a similar Phase 2 trial for a Biogen medication that is also supposed to remove excess tau from people suffering from PSP. The study is named "PASSPORT - Study of BIIB092 in Participants With Progressive Supranuclear Palsy"
Here is the link to the study:
The study is still recruiting. The drug was well tolerated in the Phase 1 trial, and showed considerable reduction of tau in the cerebellar spinal fluid of participants.
Here are the requirements to participate:
Ages Eligible for Study: 41 Years to 86 Years (Adult, Senior)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Key Inclusion Criteria:
Participants with probable or possible PSP
Able to ambulate independently or with assistance
Able to tolerate MRI
Have reliable caregiver to accompany participant to all study visits
Score greater or equal to 20 on the Mini Mental State Exam (MMSE) at screening
Participant must reside outside a skilled nursing facility or dementia care facility at the time of screening and admission to such a facility must not be planned
Key Exclusion Criteria:
Presence of other significant neurological or psychiatric disorders
Diagnosis of amyotrophic lateral sclerosis (ALS) or other motor neuron disease
History of early, prominent rapid eye movement (REM) sleep behavior disorder
History of or screening brain MRI scan indicative of significant abnormality
Known history of serum or plasma progranulin level less than one standard deviation below the normal patient mean for the laboratory performing the assay
We are thrilled to be a part of this and are feeling hopeful for the first time in many months. Anyone who is interested can go to the link to find out more. You can also google BIIB092 .
Wish us luck!