Cannabinoids remove plaque forming proteins from brain cells.

[Mnd0vrmnky]

This was in the news recently.

salk.edu/news-release/canna...

Here is the science behind the endocannabinoid system in the human body.

researchgate.net/publicatio...

I had been giving my dad thc oil in capsule form at night to help him sleep. He loved them initially, but then he started breaking his computer without knowing how to fix it. He's normally a computer wiz. And he was having bad days, one after the other. Like the disease was progressing every day. It got to the point where they were considering cancelling their cruise. We didn't want them to take any of the thc pills through customs or anything so we decided to take him off them. Immediately he was back to his normal self. Wasn't bouncing off any walls, fixing his computer no problem. He was back to how he was before he took the thc pills.

I'm not an expert but my opinion was that the thc was shrinking the brain at night allowing it to clean itself better than normally. But because I'm no expert we decided it was quite possible that the pills were causing the disease to progress and he should not take them anymore.

After reading the new info we are rethinking our position and I think we are going to try ground cannabis in capsules rather than the higher strength oil we tried initially. This way we can control the dose better and start of really low and build it up until we notice anything bad and back off a bit. We will use cannabis that is 1:1 thc/cbd. This will minimise the psychoactive effect of the thc.

There is a legal thc mouth spray made in the uk and available from the NHS called Sativex, but it's only allowed to be given to ppl with MS. With this new info I would hope they might expand upon this and allow ppl with Neurodegenerative diseases like Alzheimer's, Parkinson's, PSP, CBD, MSA etc access. In fact, we should start a petition.

[Mnd0vrmnky]

Cannabinoid receptors in the brains movement control areas, the basal ganglia and the cerebellum. ncbi.nlm.nih.gov/pubmed/165...

[easterncedar]

PSP is caused by tau protein tangles and the THC targets the amyloid beta plaques, right? So not much use for us?

[Mnd0vrmnky in reply to easterncedar]

You are correct, the amyloid is not what we have, but the basal ganglia and the cerebellum (Psp central) do have dense clusters of cb1 and cb2 receptors. It's just a matter of time before we discover what they do in that part of the brain. But I can just about guarantee anti inflamation is one of those things.

I just copied and pasted this next bit from this page

medicalmarijuanainc.com/par...

Evidence suggests that cannabis could potentially slow the progression of Parkinson’s by providing neuroprotective effects. The cannabinoids found in cannabis are able to suppress excitotoxicity, glial activation and oxidative injury that cause the degeneration of the dopamine-releasing neurons. In addition, they improve the function of cell’s mitochondria and activation of cellular debris clearance, further encouraging neuron health (More & Choi, 2015) (Garcia-Arencibia, Garcia & Fernandez-Ruiz, 2009) (Lastres-Becker & Fernandez-Ruiz, 2006) (Zeissler, et al., 2013). Researchers have found evidence that one specific cannabinoid found in cannabis, tetrahydrocannabinol (THC), helps in the treatment of Parkinson’s disease by assisting in the prevention of damage caused by free radicals and activating a receptor that encourages the formation of new mitochondria (Zeissler, et al., 2013). Another major cannabinoid found in cannabis, cannabidiol (CBD), has also demonstrated its ability to support the health of neural cells mitochondria, causing the researchers concluded that CBD should be considered as a potential therapeutic option in neurodegenerative disorders like Parkinson’s because of its neuroprotective properties (da Silva, et al., 2014) (Zuardi, 2008). - See more at: medicalmarijuanainc.com/par...

The bits that excite me are the bits about improving the function of the mitochondria, activation of cellular debris clearance and encourages the activation of new mitochondria. This in a different area of the brain due to it being parkinsons, but there are dense clusters of cannabinoid receptors in our areas of the brain. The Basal ganglia and the cerebellum.

ncbi.nlm.nih.gov/pubmed/215...

[Mnd0vrmnky in reply to Mnd0vrmnky]

ncbi.nlm.nih.gov/pubmed/182...

[abirke]

I am a believer in Cannabis acting as a health agent....We have seen it so long only as a toy, that pot has gotten a bad rap from the conservative peoples who are politically stronger but not very knowledgeable....I also wonder...all those 70 year old Vietnam vets who started smoking when they were 17 and are maybe still doing it, Do a study on them....whats the incidence of those diseases controlled by CBD and THC in those studies I just read about! I mean we have so many people out there who have some form of CBD and THC running through there bodies. Do their gene markers test positive for ALs, Alz and other maladies of life and yet do not have any of these maladies...granted the quantities and qualities were not controlled ,but it's still worth looking into isn't it? Just a thought thanks for the info

AVB