I was on TRT prior to my diagnosis. When my PSA was over 4, my doctor took me off of TRT. That was in March 2023. I experienced and continue to experience the typical side effects of low T. My Gleason Score was 4+3 and the cancer was localized and confirmed by a PSA- PET scan. My PSA never exceeded 5.7.
I had SBRT in February/March 2024. My testosterone level was recently 7.65 and PSA was .04. I’ve read that when patients begin using TRT again after having prostate cancer that there is no discernible difference between those using TRT and those who don’t.
I would like to begin TRT again, but my RO appears hesitant. My urologist said he would put me back on TRT immediately. Does anyone have experience with TRT after SBRT?
Thank you!
Written by
Victor615
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When did you finish ADT? That is a relevant question. Some say TRT 18 months after ending that is normal but that is a long time for someone that already had low T to begin with. Plus there are some new theories that low testosterone actually encourages PCa. Or at least that is how I read a recent post about a study. Something about low T leaves an androgen receptor by itself, whereas higher T the receptors couple and ward off cancer. or something like that. But 7 is super low. That is close to zero. So probably wouldn't apply to that. But it makes it appear you are still on ADT.
Like you, I had hypogonadism before prostate cancer. I've completed 6 months of Orgovyx and SBRT. My PSA is now 0.02. My plan is to start TRT very soon (~ 1 month). Of course, I will monitor my PSA on a frequent basis, and adjust T levels as needed.
I, too, was on TRT prior to all of this. I start SBRT at UCLA next week and they want me on ADT. Did you even take ADT? ADT after TRT seems like a double whammy to the system!
I had 5 sessions of SBRT about 8 months ago, and just completed 6 months of Orgovyx. I have a complicated history of microadenoma on my pituitary gland that caused my hypogonadism. A recent MRI showed that the pituitary tumor has disappeared, so I'm wondering if my T will now recover naturally to normal levels without doing TRT. Stay tuned...
I consulted with Dr. Kishan at UCLA....he was great ! You're in good hands at UCLA!!
You may want to ask Dr. Kishan about using low-medium dose estradiol patches to alleviate the symptoms of hot flashes and osteoporosis from traditional ADT treatments (Lupron, Orgovyx). Recent Phase-III results from the PATCH trial reported that you can replace traditional ADT with estradiol patch ADT safely and effectively.
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