Dutssteride increases PSA Doubling Time by 2X for men with PSA Failure.

[janebob99]

These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to PSA Failure.

In the upper plot, Dutasteride increases the Doubling Time from, for example, 9 months to 18 months (factor of 2X).

In the lower plot, Dutasteride increases the Time to Disease Progression (intent to treat) from, for example, 9 months to 18 months (factor of 2X).

Dutasteride reduces DHT levels by more than 90%, and DHT is what "fuels" prostate cancer growth. Plus, it treats Male Pattern Baldness!

pubmed.ncbi.nlm.nih.gov/231...

Thanks to Kanzan for posting this article!

[Cooolone]

Thanks for posting!

[dhccpa]

Is PSA failure the same as castrate resistance?

[janebob99 in reply to dhccpa]

Yes, I believe they are the same.

[Yearofthecow]

That article is from 2012, and the sample size is pretty small, only 294

[janebob99 in reply to Yearofthecow]

294 seems like a lot of men to me...