Magnetic Resonance Spectroscopy

[ElLayhiker]

Have contra-indications from multi-parametric MRI (4/2023) and latest serum PSA (4.4 ng/ml, 9% free PSA). SO recommends retest and another MRI in 6 months. Verifying that prev MRI did not include spectroscopy. Im thinking MRI w spectroscopy is the next step if it wasn't part of previous MRI.

[Tall_Allen]

What do you mean by "contraindications"? MRS is rarely used but had some interest experimentally.

RSI-MRI is something they do at and you may qualify for their clinical trial at UCSD - Tyler Seibert;

prostatecancer.news/2016/08...

classic.clinicaltrials.gov/...

[ElLayhiker in reply to Tall_Allen]

Contraindications = free PSA <10% (55% chance of malignancy for my age group) vs previous multiparametric MRI negative for PCA. Specificity for MRI is 38-93% or thereabouts, hence my interest in spectroscopic MRI. This technology has matured quite a bit over the past few years and it's my understanding that it's available at UCLA. Phased array receiver coils have provided impressive reductions in interference and noise. Choline:citrate ratio seems particularly useful in detecting malignancy.

[Tall_Allen in reply to ElLayhiker]

I don't think you can get MRS outside of a clinical trial - let me know if you do.

Prostate Health Index (PHI) has greater specificity than % free PSA (which is part of it).