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Prostate specific antigen (PSA) recurrence—defined as a PSA level higher than 0.2ng/mL—occurs in 20 to 50 percent of all radical prostatectomy cases. 18F-DCFPyL PSMA PET/CT detected disease in 46.9 percent of patients compared to 15.5 percent on diagnostic CT. Major changes in the treatment plan were more likely to occur after PSMA imaging (12.5 percent) than after CT imaging (3.2 percent), and moderate changes were noted in 31.3 percent of patients after PSMA imaging versus 13.7 percent after CT imaging.