TO TAKE OR NOT TAKE ORGYVYX HORMONE WITH CARDIAC PROBLEMS.

[JWS13]

I am scheduled for SBRT on 1/12/ 23 at UCLA. They are recommending 4 months of ORGYVYX/Regulix.(ADT HORMONE) (I have Afib , and other CARDIAC comorbidities. ...)

The Decision whether to take the 4 months of hormones is driving me nuts! (analysis/paralysis) .

I am concerned that if I don't take it, I may be good for 5 years and then there is a 10% increase in my recurrence rate to 30 % because I did not do the Hormone.

I have researched the "salvage " treatments currently available after recurrence(Cryo, Hifu, HDR Brachy) and all of them are flawed (50% failure rate)...

Which means if I don't take the Hormones now for 4 months , I could be on Hormones 5 years from now for the rest of my life, EXACTLY WHAT I WAS TRYING TO AVOID.

I am SPECIFICALLY asking has anyone who has taken Hormone therapy has had ANY TYPE OF ACTUAL CARDIAC SIDE EFFECT , (i.e afib, heart attack, arrythmia, etc. ) or mostly other SE's.

I have not seen anyone post with a Cardiac Side Effect from Hormone Therapy ???

This will help very much ...Thanks to you all and Happy Holidays!!

68 Gleason7 (4+3 ) , PSA 10

[Tall_Allen]

I assume you are taking a blood thinner. The numbers are small -- Fatal and non-fatal myocardial infarction and stroke were reported in 2.7% of patients receiving ORGOVYX. Why not ask your cardiologist?

[JWS13 in reply to Tall_Allen]

I did yesterday and he says he has no data on it that would be helpful...it's too ambiguous..too many individual variations..he indicated that the SE pamphlet is CYA and he did not find specific trials on ORGOVYX...

[Vynbal]

I was diagnosed with PCa in April 2021. I also have Brugada syndrome, a genetic cardiac sodium channel defect that can lead to fatal arrhythmia. When I started 6 months of ADT, it was with Orgovyx, with weekly EKGs, looking for dangerous changes. We (me and my medical team) were prepared to stop the Orgovyx if necessary. The QT interval noticably lengthened, but stayed in the safe range. I completed 6 months with no cardiac incidents.

[Mike404]

I’m four months into a six month run of Orgovyx. I’m diabetic, but no specific cardiac issues. No side effects from the ADT. My T level is at 12, less than an old lady’s, and my PSA is undetectable. Also SBRT at UCLA. It’s been a non issue for me and well worth the possible benefits you point out. Better a short run now than a long run later.

[maley2711]

I will add that the success rate may be lower, but SBRT without ADT will still have a good success rate.......and the 50% failure rate for salvage is also a 50% success rate.. I would just guess any enhanced cardiac problems with Orgovyxx are similar to those seen with Firmagon, etc. There are studies on cardiac issues when using the other ADT options. As I recall , the problem is very small, but not zero....eg 1%? Google or Pubmed should help find studies for you. Lucky is the man who is only asked to tolerate ADT for 4 months....best luck with your treatment.

[Murph256]

I had a heart attack in July of 2020 and had three stents put in. And I’ve been on and off ADT for four years now, including a 12 month stint on Orgovyx that ended earlier this month. I’m sure the Orgovyx is not good for my heart, but I go in for biannual EKGs, along with periodic echocardiograms and stress tests. My cardiologist never seems too concerned. I did drop my Brilinta prescription as it’s a blood thinner. But my platelets are already low at 116 due to my EBRT, so I had no need for a blood thinner. I will say this, the Orgovyx seems to have milder side effects than the Lupron I was on several years ago, including a milder effect on my heart, I hope. Life is a balancing act. Currently, I feel my PC is a greater concern than my heart condition. Good Luck!

[Scooter22]

Intermediate unfavorable, psa 19. Determined to be localized. Began Orgovyx in Oct. 2021, 4 wks. b4 my 1st sbrt treatment. Sbrt treatments ended right b4 Thanksgiving 2021. My MO recommends 2 yrs. of adt for my level of disease. We had a discussion about ending the adt at the 18 mo. interval but I’ve decided to go ahead and do the 2 yrs.. I’m sure I’d regret it if there’s a reoccurrence. Orgovyx is not that bad FOR ME. I’m an exerciser & always have been. I walk every day & lift every other day. As long as I’m busy & active I feel pretty good. That said, I’m looking forward to getting off it as I’ve lost strength & I do worry about the secondary effects of the adt. My lipid panel did elevate but I’ve begun a botanical supplement regimen that is bringing those numbers down.

[JWS13 in reply to Scooter22]

Thanks for response...what is a "botanical supplement regimen"that brings cholesterol down?

[Hidden in reply to JWS13]

Maybe berberine? Supposed to be similar to metformin. Me? I asked for and got a metformin prescription. Others here will argue, but supposed to be beneficial in suppressing prostate cancer.

[Scooter22]

I take quite a few things- Quality fish oil, Berberine, Heart Savior, baby aspirin, magnesium.

[Teacherdude72]

Since G9 diagnosis in 2015 I have been on Lupron twice. First time 24 months and now since aprox 2 years ago. I am also on Nubeqa this time. No mets.

No heart issues! Never smoked nor heavy drinker. over weight. Losartan and Eloquis.

Read,ask questions of your medical team and monitor often.

Be well and enjoy life.

[Hidden]

I have a long history with a-fib. I took meds for it for many years. In the time I had my six-month eligard shot I had zero episodes. None. My heart behaved better on eligard. Your experience might be different but I wanted to relate my experience. That was six years ago. Two years ago I had a-fib ablation surgery after the meds I was taking failed to prevent episodes and Covid was threatening too. So I had a serious case of a-fib.

[JWS13 in reply to Hidden]

did u have an ablation? was it successful?

[Hidden in reply to JWS13]

Yes the ablation was successful. Done here in Phoenix.