Docetaxal is considered ineffective due to a rising PSA. 4 sessions completed a increase of 2.7 to 9.3 now leap frogging to a phase 1 trial

[Costarica1961]

I am not sure how things accelerated to a phase one harpoon clinical trial. According to my oncologist, and my new prostate doc they believe based on the trouble some PSA increase it may be time to explore other options. I suggested 3 potential ideas that I had thought were possible options parp inhibitor was my first thought, although it was determined by a gene specialist that i am not a candidate. I asked about cabataxal the doc stated, he thought the results would be short lived and not effective, he felt the same way about radium 223. So I am left with a weekly infused harpoon trial . I live 80 miles away and this would be a weekly drive until it is no longer effective. The side effects are minimal according to the doc in comparison to chemo. The doc was not able to tell me how the current participants are doing in this trial, I thought that would be valuable information, this is the biggest decision of my life. Any thoughts.

[Hidden]

Go for it . No looking back . This could work for you .

[Tall_Allen]

Here are the side effects of a similar trial:

meetinglibrary.asco.org/rec...

The Amgen 160 trial is further along and they have added Keytruda for sustained effect. I think they do the AMG160 it in a single infusion, but Keytruda is given more frequently..

[Rexwaterbury]

It’s a huge commitment I agree. I have been offered this trial as well, but do not live close to a trial location. It would require that I uproot and relocate, probably from Virginia to Southern California, where I have family, to participate in the Amgen trial which is similar. No easy decision.