Searched here for "Embelin" and found nothing

Yet, Embelin or Vidanga sounds interesting.

1) "Embelin-Induced Apoptosis of Human Prostate Cancer Cells Is Mediated through Modulation of Akt and β-Catenin Signaling" (2015).

"... Embelin, isolated as the active component of the fruit of Embelia ribes Burm, is one of the important small molecular inhibitors of XIAP that has been identified using computational screening from natural product library. Previously, embelin is known to suppress cell proliferation and to induce apoptosis in various human cancer cells. Consistent with previous results, in this study, we showed that embelin is able to inhibit cancer cell growth through induction of apoptosis. The cytotoxic effects of embelin were greater in human prostate cancer cell lines than the other cell lines or prostate epithelial cells, although the reasons for this difference are not completely understood..."

ncbi.nlm.nih.gov/pmc/articl...

2) "Embelin, a small molecule quinone with a co-clinical power for castrate-resistant prostate cancer" (2014).

"... Adverse reactions such as reproductive system and breast disorders, breast tenderness, gastrointestinal disorders, hot flushes, nausea, diarrhea, hepatic disturbances (elevated transaminases levels and jaundice), erectile dysfunction, significant hypersensitivity reactions and drug resistance has been reported with antiandrogen agents like Bicalutamide, Dutasteride and MDV3100 in clinics. A small molecule quinone, Embelin (2,5dihydroxy-3-undecyl-1,4 benzoquinone) the major active constituent derived from the fruits (2.3%) of Embelia species (local name; Vidanga) has been known since antiquity in the indigenous systems of medicine well-documented for its antifertility, potent antioxidant and anti-prostate cancer properties..."

frontiersin.org/articles/10...

3) "Natural IAP inhibitor Embelin enhances therapeutic efficacy of ionizing radiation in prostate cancer" (2010).

"... In this study, we found that embelin enhances therapeutic efficacy of radiation therapy in human prostate cancer PC-3 both in vitro and in vivo. Embelin combined with X-ray radiation achieved increased tumor growth inhibition and apoptosis, which is accompanied by the embelin-induced cell cycle arrest in S-phase. Moreover, the combination treatment increased caspase-independent apoptosis but not autophagy..."

ncbi.nlm.nih.gov/pmc/articl...