I have read Snuffy Myers videos about Metformin and the limited evidence he cites as well as others support its use for non-diabetic PCa patients. However, since the clinical evidence is not conclusive, I have had some problems in getting a prescription either from a PPP or even 2 prostate cancer oncologists. I finally got a prescription from my local urologist after citing a scientific abstract on Metformin's value. Myers says takes 0.5-1.5 years to have any impact and normal max dose of 2,000 mg must be gradually attained because of diarrhea. I have a prescription of 500 mg, now and will continue until see it has any effect on PSA. I did have recurrent PCa, been treated, and am monitoring now, PSA=0.04. Any advice or experiences on value of Metformin and higher dosage?