Metformin and rosuvastatin

[twostrats79]

It is hard to find a report/article on Metformin's possible positive association with PC that is not full of medical speak. How does anyone know if their NKX3.1 is low or high? 3 years ago I was diagnosed with unfavorable Gleason 7, with an initial psa of 6.4. Three months later I had an RP and have been undetected since. This week I started taking metformin for high sugar levels, I have also been on first atorvastatin and now rosuvastatin for 3 years. I am 5' 9" and 167 lbs. I wonder if the metformin and rosuvastatin will play a part in keeping the pc at bay.

[Tall_Allen]

Probably very tiny effect if at all on PCa from statins or metformin. NKS3.1 is just a biomarker for PCa - not something to worry about.

[Dont08759]

I’ve been taking Metformin and a statin (Rosuvastatin for the last 2 years) for a decade before I was diagnosed with PC on the right side only (Gleason 9) 6 years ago. Two years post op a cryo hemiablation of the right side of my prostate, my 18 core biopsy showed Gleason 9 on both sides so I’m skeptical of any benefit from those drugs. But, remember, N=1 is never great research… PS still taking both meds…

[Seasid]

cuimc.columbia.edu/news/dia...

it could help you a lot if your cancer is aggressive.

Good luck.

[Mlnb11]

If your interested, the book 'How to Starve Cancer' by Jane Mclelland does a deep dive into metabolic pathways and she addresses this very issue. Metformin and a statin address only a couple of the pathways that cancer is fed. All pathways should be blocked in order to starve cancer. She gives a lot of research to back it up. Good luck

[rlafford]

You might find research by Boston College prof. Dr. Thomas Seyfried of interest. He has produced some very interesting studies on cancer metabolism and the use of a low carb, ketogenic diet with a daily fast to slow / stop cancer growth. tomseyfried.com/