The prognostic value of ultrasensitive PSA test

[ulfhbg]

Hi !

In Sweden (and Finland) we never (or selldom) have ultrasensitive PSA testing so the lowest PSA is < 0.1 or ’undetectable’.

i have seen several discussions regarding ultrasensitive PSA measurments and I can understand the value after prostatectomy because you have removed the major source of PSA in your blood.

But for us with the prostate left, radiated for example and perhaps on ADT. Is there any significant value of trying to get a ultrasensitive PSA measurments?

Like I said, I can understand the use of it after prostatectomy or perhaps even after radiation and ADT and when it’s time to stop ADT.

But, what value do you bring to the table knowing more decimals compared to < 0.1 from a prognostic perspective?

Best wishes - Ulf

[Tall_Allen]

"But for us with the prostate left, radiated for example and perhaps on ADT. Is there any significant value of trying to get a ultrasensitive PSA ?"

Even less value after radiation, because biochemical failure is not suspectected until nadir + 2.0 is reached.

[ulfhbg in reply to Tall_Allen]

Hi TA !

Thanks for a clear respons. Have you seen any studies or documentation that a PSA value of < 0.01 is a predictor of how long you need to stay on ADT and if so; what are the findings on how long you need stay on ADT?

Well, just curious anyway for me as in Sweden we only do to < 0.1 as a standard measurment.

// Ulf

[Tall_Allen in reply to ulfhbg]

The duration of ADT is based on the protocol you are following.