Methotrexate and Sulfasalazine

[JHMQ]

Has anybody got personal experience of the use of these drugs for the treatment of polymyalgia?

[PMRpro Ambassador]

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There are lots who have been on methotrexate but I don't think many have used sulphasalazine - it doesn't have much of a record in PMR. The first rheumy I saw for the PMR diagnosis was totally insistent that it wasn't PMR despite the 6 hour response to 15mg pred and wanted to use sulphasalazine - I was about to move here to Italy and didn't have a consultant so it had to be postponed. It has never been mentioned here and I never took it. I tried methotrexate but only lasted a month because the fatigue was overwhelming and I stopped it to be able to function.

[Mamamia21]

I eventually tried Methotrexate as a steroid sparer after yoyoing for many years. I didn't have any side affects and am now heading to 1mg of prednisolone and feeling well. When I decided to give it a try I too was worried about putting yet another drug into my body but if you get to the stage where reducing your steroids is impossible it felt like it was worth a try and it paid off for me. At least Methotrexate can be stopped fairly quickly if it doesn't work for you and that was the reason I tried it. I hope this helps.