Vomorolone is not currently approved for use in treatment of PMR. I'm just posting this so everyone is aware of its existence. There are also currently no clinical trials for its use with PMR, but here is what preplexityai.com says:
perplexity.ai/search/are-th...
Just thought you all might want to start discussions with your docs. Vomorolone has less side effects than prednisone, so it seems to have promise.
Vamorolone was not approved for the treatment of DMD (Duchenne muscular dystrophy) in UK in January this year. They said “Vamorolone is an effective treatment for DMD, but its relative effectiveness compared with other corticosteroids was highly uncertain… [and] there was not enough evidence to conclude that vamorolone is a cost-effective treatment option.” It looks like it will not be approved for PMR in the near future.
Usual story no doubt - the makers singing its praises without any independent evaluation. And then the clinical trials show the truth.
The 2022 studies linked below suggest vamorolone (Agamree) is not superior to prednisolone, but it is a bit different. For example, it is usually swallowed in a tiny amount of liquid, and it penetrates the brain much more readily (which is not necessarily a good thing). "Bone turnover markers declined with prednisone but not with vamorolone. Boys with DMD at baseline showed low ACTH-stimulated cortisol and high incidence of adrenal insufficiency. All 3 treatment groups led to increased adrenal insufficiency."
Vamorolone has its own extensive list of potential side effects, just like all corticosteroids. They include the development of cushingoid features, psychiatric disorders, vomiting, weight gain, vitamin D deficiency, and cough.
The normal dosing regime for patients with DMD (Duchenne muscular dystrophy) is 0.75 mg/kg/dy of prednisolone, but 2 to 6 mg/kg/dy of vamorolone, which suggests the new drug is much less potent.
Shingles and Prednisone 
Discontinuation of prednisone
Prednisone Dosage
Prednisone vs Methotrexate
