I really need to take some pantoprazole; however, it seems to not go well with MTX in particular. Before I started MTX (20 mg), I sometimes took pantoprazole 40 mg for 2-3 days to get rid of pain from reflux. It would settle, and I would be fine for a long time.
Any experience with pantoprazole while taking MTX?
In what way does it not go well with MTX?
I had a month of 40mg pantoprazole after my cardiac ablation - horrible, brain fog, was so glad when I finished the course!
It says on the internet that there’s interaction. Also in the MTX patient information leaflet. It is not contraindicated though. Just that it can aggravate the toxicity of mtx
Right - had time to look now. The pantoprazole slows the rate at which the body excretes the MTX so potentially you may get the effects of a higher dose than you were given. However, this is primarily when MTX is used at high doses in oncology (cancer treatment) where they are using much higher doses such as 1g per square metre body surface area and that can be starting at about 2.5g at a time - compared to 25mg maximum in rheumatology that is a thousand times as much.
So with low dose MTX in rheumatology it shouldn't be too much of a problem.
Pref Mtx and antibotics
Tapering below 10mg steroid on MTX and TCZ
After much debate trying MTX 
MTX taken by injection
