The MELODY study has been published! I
Short summary of the MELODY study paper
COVID-19 can be a serious infection that can lead to treatment in hospital or even death. We know from previous research that people who have a weakened immune system were more likely to catch COVID-19. The MELODY study aimed to find out how well vaccines protect people who have a weakened immune system from COVID-19. We invited people who have had transplants, people with certain types of blood cancer and people with rare autoimmune rheumatic disease to take part.
We found that about 4 in 5 people that took part in MELODY had had antibodies after having 3 or more vaccines. People who had more doses of vaccine were more likely to have antibodies.
We now know that most immunosuppressed people make antibodies after having a COVID-19 vaccine. We also know that the more vaccines you have, the more likely you are to have antibodies. Therefore, we recommend that people have vaccines and booster doses as offered by the UK vaccination programme.
The published paper and a commentary in Lancet Rheumatology can be found here: