IS PMR HEREDEITY. : Does any know if PMR runs in... - PMRGCAuk

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IS PMR HEREDEITY.

Harrywogan profile image
41 Replies

Does any know if PMR runs in family, as I remember my mum being in hospital to get bloods sorted anshe had inflammation of the muscles P M R was never mentioned at the time.

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Harrywogan profile image
Harrywogan
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41 Replies
jinasc profile image
jinasc

This is often asked some of our parents and grandparents did have aches and pains often not diagnosed or just put to the arthritis. My Mam had both PMR & GCA.....21 years later I ended up with GCA only.

Freya will be along shortly and will give you a link to a light 😍😍 ed post on this subject

I am Hel..............it was the blooming Vikings 'wot dun it'

However the question is still out with the jury.

DorsetLady profile image
DorsetLadyPMRGCAuk volunteer

Not as in some diseases, but as it’s connected to lifestyle and environmental factors, it’s quite likely that members of tge same family -whether close or more distant get it.

As jinasc says -lighthearted look at subject -

healthunlocked.com/pmrgcauk...

Kendrew profile image
Kendrew

Hi there,

Everything I've read suggests there's not a hereditary link and both GP and rheumatologist suggested the same. Having said that, my father had PMR/GCA for the last 8yrs of his life and my sister for 3yrs. So there seems to possibly be a hereditary predisposition to developing it?

Telian profile image
Telian in reply toKendrew

I’m the eldest of seven and one brother has PMR. The predisposition theory could be so there. Three of us have MS plus my niece, daughter of the above. Don’t know of any previous family that had it. Can miss generations though.

PMRpro profile image
PMRproAmbassador

It isn't hereditary in that there isn't a gene that causes it that can be passed from generation to generation like with cystic fibrosis or muscular dystrophy. However, there is a pool of genes that makes it more likely that you could develop PMR and you have the same pool of genes as your parents, grandparents etc.

Bit like the suntanning predisposition - if your family all tends to go brown, you probably will too. But you DO need to go out in the sun to go brown. Same with PMR: the predisposition is there but it takes other factors to flick the switch - environmental, chemical, illness, accident, to cause stress on the immune ssytem. And of course, you usually share at least some of those factor with the family if you lived with them for a long time.

Kendrew profile image
Kendrew in reply toPMRpro

Thst makes it all feel much more relatable. I can make sense of that.

piglette profile image
piglette

I have heard that it is thought that some families’ genes are prone to auto-immune diseases. My mother had ME and my niece is Celiac.

RoomsonFire profile image
RoomsonFire in reply topiglette

Yes I think it’s Likely- My only Sister and I have RA , PMR , our Children Diabetes, ME , Fibromyalgia- So we may have a Weakness - But I was Ok until the Covid Vaccine and Shingles sent my System into a Spin ! At age 60 - So could have drawn a shorter Straw I guess 🙏🥰

Knit11 profile image
Knit11 in reply topiglette

My GP suggested that the presence of arthritis in the family shows as PMR with me.

piglette profile image
piglette in reply toKnit11

I personally would disagree with your GP!

DorsetLady profile image
DorsetLadyPMRGCAuk volunteer in reply toKnit11

Arthritis is not the same as PMR...arthritis affects joints, PMR is affects muscles surrounding joints.. arthritis v arteritis... would agree with piglette

Knit11 profile image
Knit11 in reply toDorsetLady

Thank you both! I appreciate your comments. My doctor didn't suggest that it is a similar disease, only that it is a gene manifestation. That arthritis, which exists in my family, may have created predisposition to PMR. Whether it is on not, there's nothing I could have done about it anyway.

DorsetLady profile image
DorsetLadyPMRGCAuk volunteer in reply toKnit11

Maybe, maybe not, there is arthritis in my family - can recall my grandmother having it badly, can't recall my mum or auntie having it, my sister worse than me...but I'm the only one who's had GCA... Lucky me, 😅🤣

Knit11 profile image
Knit11 in reply toDorsetLady

:) we are the special ones!

DorsetLady profile image
DorsetLadyPMRGCAuk volunteer in reply toKnit11

Not sure whether that's good or bad...but I can guess what my kids would say....

Knit11 profile image
Knit11 in reply toDorsetLady

Haha, one of my sons freaked out and already asked his GP what can he do to avoid getting it. She told him to eat well and exercise... (duh! When they tell you this you know they have no effective answer).

PMRpro profile image
PMRproAmbassador in reply toKnit11

I ate well and was quite a gym bunny ...

DorsetLady profile image
DorsetLadyPMRGCAuk volunteer in reply toKnit11

Oh Lordy……

PMRpro profile image
PMRproAmbassador in reply toKnit11

There are specific genes associated with some forms of inflammatory arthritis - and they aren't found in PMR

PMRpro profile image
PMRproAmbassador in reply toKnit11

What SORT of arthritis? There are over 100!

Knit11 profile image
Knit11 in reply toPMRpro

Psoriasis

PMRpro profile image
PMRproAmbassador in reply toKnit11

It has a strong genetic basis, loads of genes associated with it. But to my knowledge they haven't identified any for PMR ...

Knit11 profile image
Knit11 in reply toPMRpro

Thanks! You have a lot of knowledge.

Queenie1901 profile image
Queenie1901

I have no scientific answers but my mother had diagnosed PMR in the 1990s and her mother, my grandmother, probably had it too but was undiagnosed back in the late1960s/early 1970s. Her GP told her the pains in her shoulders were from carrying a handbag which wss too big and too heavy! (And it was!) If you compare lifestyles my mother's was much less stressful than mine. On my father's side, his brother had PMR and his was an exceedingly demanding lifestyle. For me, I have decided that my life events and my professional life demands (teaching) have probably been the culprit on top of any gene pool which PMRPro mentions.

Oboes22 profile image
Oboes22

Strange you should ask this and I know the jury is out in this question but my mum had SLE (lupus) and took prednisolone for the last 15 years of her life. I also have a cousin in Oz who has an autoimmune disease so……. Stay safe

Nominem profile image
Nominem

My late mother had pmr ..I have had an onset of gca at73.

Jane424 profile image
Jane424

Both my sister and myself have PMR, also we have multiple autoimmune illnesses in close family.

AncientMariner profile image
AncientMariner

From what I have read GCA is more commonly found is people of a Scandinavian origin, although it is not exclusive and of these the significant majority are female. The females on my Father's side are preponderantly red headed and my Grandmother went blind and suffered crippling Arthritis. Her Sister also suffered from Arthritis and her son, my Uncle was in a wheelchair at age fifty. My Aunt on the same side is red headed and takes Methotrexate and has Arthritis in the spine. My Mother is from Dublin a Viking colony so if that's anything to go by I've had it, I'll make the best of it and attach Dragon heads to my wheelchair or a fetching sail perhaps😂

DorsetLady profile image
DorsetLadyPMRGCAuk volunteer in reply toAncientMariner

Sure you've read my Vikings post.....if not it in my reply to Harry ..

Sharitone profile image
Sharitone

No one in our family has it, that I know of. If they had, then maybe my mum would stop telling people it's all in my head, and I just can't cope. Grrr!

PMRpro profile image
PMRproAmbassador in reply toSharitone

Just the sort of mum anyone needs - NOT. That is not nice

Sharitone profile image
Sharitone in reply toPMRpro

🥴 No, but then, why change the habit of a lifetime?

PMRpro profile image
PMRproAmbassador in reply toSharitone

True. Mine never seemed too keen on me, little bruv was definitely the favourite, but she was never that nasty.

Suet3942 profile image
Suet3942

My mother had both gca and pmr and I think maybe her mother had it but would have been undiagnosed then. My first rheumy said he was treating a woman and all 3 of her daughters.

ackagee profile image
ackagee

I have a cine film I took of my Dad in 1976 walking with my son who was 2 years old at the time. Dad - who was 87 years old at the time - is clearly doing the 'Poly Waddle' - as I do now since I was diagnosed with PMR in December 2017. Dad died in 1978: he had lost a lot of weight in his final years, he struggled with paperwork in his library and needed a long nap every afternoon. I think he could well have had PMR although I'm not sure the local country GP in the UK would have known much about it all those years ago. We are definitely descended from the Vikings.

Nextoneplease profile image
Nextoneplease in reply toackagee

Interesting 😊 Can anyone describe the ‘poly waddle’ to me please? I think I have it but I had associated it with arthritis- it’s taken me a while to realise it’s probably linked to PMR stiffness in my hips and thighs x

ackagee profile image
ackagee in reply toNextoneplease

When the knees have been damaged by PMR, one tends to walk like a duck: at this point, one can be said to be doing the 'Poly Waddle'. (Something triggered by POLYmyalgia - get it ?) I didn't come up with this name for the condition: I saw it on the PMRGCAUK website some years ago.

Nextoneplease profile image
Nextoneplease in reply toackagee

Thank you ackagee 😊

Yes, I get the POLYwaddle reference….😂

I have OA in my knees, hips and feet so associated my gait with this - but it’s been much worse lately so it seems likely PMR may also play a part x

PMRpro profile image
PMRproAmbassador in reply toackagee

I have ankle problems at the moment in the wake of a massive flare in the early part of the year and my hips are stiff - and for the first time since I went on pred I am back to the polywaddle. I realised the other day I am walking just like my great aunt did - who I am sure had PMR, she couldn't lift her arms above her head and was very crippled. I'm sure my grandfather also had it though his walk was different. That was the late 50s and early 60s when it was just "rheumatics" and lumbago - considered not to be a serious condition. No consideration it might be a sign of something serious!

ackagee profile image
ackagee

Welcome to the club of happy 'Poly Waddlers'...

Portobello profile image
Portobello

My mother had Lupus and her brother MS- both Scottish. I have PMR + 2 other auto- immune conditions. My son, aged 43, has Long Covid 😟

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