Research Future Regarding Covid Vaccine

[Bcol]

Hi all wise and wonderful ones. I've been invited to take part in the the safety and effectiveness of an investigational vaccine known as GRT-R910 as a booster to prevent Covid 19. Sponsored by Gritstone bio Inc and carried out by a team of researchers at the Well one Foundation facility at Manchester Royal Infirmary for Manchester University NHS Foundation Trust. What are people's thoughts?

[DorsetLady PMRGCAuk volunteer]

Is it a follow on from this trial- which looks as if it was done on healthy people-

manchester.ac.uk/discover/n...

clinicaltrials.gov/ct2/show...

If you’re happy to participate and they are fully aware of your existing medical issues (which I’m sure they will go through with a fine tooth comb)…then why not!

[Bcol in reply to DorsetLady]

It is a follow on from the one we tried to get on earlier and failed. Criteria is 60+years, make that with a few to spare, have received 2 or 3 doses Pfizer vaccine (I've also had 2 Astra Zenica, not sure if that is good or bad), never had Coronavirus and not currently in any other trial.

[DorsetLady PMRGCAuk volunteer in reply to Bcol]

Ok, thanks ….well good luck with it…

[Bcol in reply to DorsetLady]

I've emailed that I'm interested, will keep in touch re reply and/or developments.

[DorsetLady PMRGCAuk volunteer in reply to Bcol]

Please do!

[Bcol in reply to DorsetLady]

No problem.

[Bcol in reply to DorsetLady]

Rejected. I've already had too many vaccinations, plus they don't want to trial anything on anyone with our problems.

[DorsetLady PMRGCAuk volunteer in reply to Bcol]

Thanks for letting us know -can understand their reticence re immune compromised patients, but if they don’t trial on those patients then they are never going to get answers we would like to know. But probably not prepared to take the risk of adverse reactions….

[PMRpro Ambassador in reply to DorsetLady]

Article in the Guardian about AstraZeneca and checking diversity of trial populations

theguardian.com/business/20...

[Bcol in reply to PMRpro]

A very interesting read, thank you.

[Bcol in reply to DorsetLady]

I can see where they are coming from, but perhaps they could give those testers a choice. It was an easy choice about me as having had four vaccinations it ruled me out anyway, apparently they are looking for those who hadn't had a booster jab.

[PMRpro Ambassador in reply to Bcol]

It does all depend on what Phase trial it is. And boosters do appear to have generated a very good increase in antibodies and other markers - so a lower threshold is being looked for.

[Bcol in reply to PMRpro]

I can see that and I must admit I'm not surprised about being rejected.

[PMRpro Ambassador in reply to Bcol]

Might be another chance later.