Thanks

[Hops1865]

Thanks, I’ll give the morning a go, been taking 15mg in evening

[PMRpro Ambassador]

Did it affect your sleep? I'm assuming it is plain uncoated pred?

[Daffodilia]

Pharmacist said morning to mimic bodies natural production of ?cortisol? I had large bowl of porridge for stomach when on 15 mg

[PMRpro Ambassador in reply to Daffodilia]

That applies more for short-term use of pred so that when you stop, adrenal function is better able to wake up and resume normal action. We are on enough pred for long enough for adrenal function to be suppressed for longer.

This idea that taking your pred at 8-9am mimics adrenal function is a tad pie in the sky - the surge of morning cortisol is about an hour after you wake. If you take pred at 8.30am it isn't into the system until 9.30am - which is rather more than an hour after most of us wake. The trigger for adrenal function is a very low level of corticosteroid in the body at midnight- helped by taking the pred as early as possible after midnight, the 2am timing fulfils both that and improving early morning symptoms. And in PMR, symptom control would seem a significant factor.