dupytren's contracture and prednisone

[SandyBoots]

Greetings. I have a question that I am not sure has been asked before. I couldn't find a related post. I have PMR and am on a slow taper of prednisone, now 7 mg and feel good. I have dupytren's contracture, another condition like PMR with a strong correlation to Northern European descent. Questionnable as to whether it is autoimmune, but certainly affects connective tissue. I am having xiaflex procedure on Tuesday. They inject collegenase into the thickened cords on your hand and then manipulate your fingers straight (sounds dreadful doesn't?) I asked the orthopedist who will be doing the procedure, if it was okay to be on prednisone and his reply was, "I don't see why not." I would have preferred, "no it will be fine." Have any of you had xiaflex for dupytren's while on prednisone?

Thanks to all of you for your many thoughtful replies to so many people.

[Loco99]

Hi SandyBoots,

For selfish reasons, I’m very pleased to find at least one other person with Dupytrens! I wondered if there was anyone else on here with it. I have it in both hands but it hasn’t got to the stage of needing treatment so I’m afraid I can’t help with your query but I would guess that suddenly stopping prednisone would be more undesirable.

This website doesn’t list any interactions drugs.com/drug-interactions...

I have always wondered whether Dupytrens is related to PMR.

All of the best for your procedure and I hope it is successful.

[Hidden in reply to Loco99]

Well, I am another one with it, my farther had it and so does my older brother. Fortunately it hasn't caused our fingers to close our hands, it's just that we can't make a flat hand on a table without applying a lot of pressure. It hasn't stopped me from making and building a model steam locomotive which will pull about 6 people around a track. Unfortunately the Covid epidemic has prevented me from running it just after I completed it. As this dreadful epidemic has kept me almost in lockdown, I have started to build another one. Got to do something or I will go crazy. Pred has not made Dupytrens any worse. A surgeon I consulted for trigger finger said it was inherited from the Vikings.

[Rosina1871 in reply to Loco99]

I also have dupytrens, mainly in right hand but now developing in left. Also have PMR

[Rosina1871 in reply to Rosina1871]

I had dupuytrens before PMR

[Hidden in reply to Rosina1871]

Me too

[SandyBoots in reply to Loco99]

Thanks to all for your replies. For those of you with dupytren's too, I will let you know how the xiaflex procedure goes on Tuesday and Wednesday so you can prepare in case you have it done as well.

[Rachmaninov2 in reply to SandyBoots]

I have Dupuytrens too, and would be very grateful for any info on the procedure please.

[Suet3942 in reply to Loco99]

I’ve got it in my right hand but I think is hereditary because my daughter has it as well. Mine is not bad ...YET!!

[PMRpro Ambassador]

There have been a few on the forums - but there isn't a direct link.

You can't stop the pred suddenly anyway - and to be honest, I like the man's opinion! Covers all options ...

[scrambledegg]

Me too. I had it before PMR. Just one hand and I've had the operation (not a great success) so interested to hear how you get on.

[Loyd]

I have it in my right hand. Got it a few years before PMR. Could it be connected?

[Twistandshout]

So sorry to find yet another person with this awful condition. I thought it was rare but my surgeon said it was their bread and butter and very common. So far have had two fingers straightened and looks like another one heading that way. Has anyone found a placebo for the pain In the palms.

[Fifelassieo]

I have it too, not as bad as you, it is bending my fingers in, l find it hard to keep my hands flat

[readingbooks]

I have it too in my right hand and am on Prednisone. it doesn't need any treatment at the moment although the 2 fingers affected can be painful at times.

[Greensleeves]

My Mum has this horrible condition , from Parkinsons and TIA’s , but I’ve always been convinced she had PMR .

Instead she was diagnosed with frozen shoulders and Fibromyalgia 20 years ago .

I would say it’s even more important to be on prednisone.

I’ve had to increase for a couple of days if I’ve had any surgical procedures or been unwell with other conditions.

I’m glad you’re getting treatment at this stage .

My Mum eventually had to have the tendons cut in her arm , her PD shaking caused a serious infected pressure sore in her enclosed hand . After surgery she had to wear a cast on her broken fingers .

The orthopaedic surgeon was wonderful. He saved her fingers .

She’s lost the use of her hand but it was better than amputation . Worst case scenario.

Best of luck and wishing you well.

[DogAgilityObsessed]

I have both. But as I think Dupytren's is relatively common (along with Carpal Tunnel syndrome which I used to have) I'm not surprised to find quite a lot of PMR sufferers also have it.

I had an initial op last November/December but it didn't quite work. Then the pandemic came along. Contacted August to go back to the surgeon - until I said I was on Pred. They didn't want to risk an infection.

Meanwhile the Dupytren's gets worse and painful (but not as bad as PMR was.