Taking meds at 4 am

[georgedog]

I am somewhat reluctant but hope it is helpful to someone...I have recently (one week) started to set me alarm and take my 7 mg of predisone at 3 or 4 am each day.

I am feeling less sore and more agile ...hope it continues....My Rumh..agreed to try it. Will keep updating...fingers crossed...Georgedog

[PMRpro Ambassador]

Do you get any morning symptoms doing that?

[georgedog in reply to PMRpro]

So far it has been an overall improvement. GD.I have referred to the post explaining the inflammatory chemical{Interleukin 6} which the body produces around 4am. which reflects how are symptoms are.. Please only take this as my results so far...Look up a post "Timing of Pred doses in PMR. Thx. MJM

[PMRpro Ambassador in reply to georgedog]

I know all the background - but taking the pred only at 3-4am means the inflammatory substances are already there before the pred is inthe system - it must be absorbed from the stomach first and if it is prednisone it must be processed in the liver to become prednisolone so that is a good 2 hours.

[Maisiek]

How do you find your evenings are? Jill

[georgedog in reply to Maisiek]

No real challenges...I run out of steam early dinner hours but no more than before.

[nickm001]

If you goal is to beat 4AM cytokines at the start, you may have better results if you take steroids 2 hours BEFORE, about 2am or so. That is how long it takes to achieve absorption and max dose in the blood stream. I go to bed late, and take them about 1am or so and have been doing that for several years. It helps to start day without usual stiffness typical for PMR.

[Bcol]

I take mine around 02:00 which seems to be working OK. Peter

[Pixix]

I take mine between 2 and 3am each morning & have done since a couple of months into the disease. I don’t sleep that well due to pain from other conditions & never set an alarm. I eat one biscuit & take lanzoprozole at the same time...I must admit I thought 4am is a bit late. It definitely improved my ‘can’t get out of bed in the morning issues’! Hope it helps you!

[chillingandrecycled]

I am also setting my alarm for approx 3.30 as I was really stiff and pained for quite a few hours (after taking about 7) whilst on lock down. I am in the process of returning to work and also tapering and couldnt even consider functioning normally as the pain and stiffness was just too severe. So far so good.