PMR following osteoporosis treatment with Aclasta - PMRGCAuk

PMRGCAuk

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PMR following osteoporosis treatment with Aclasta

Gotgoat profile image
6 Replies

This is my first post but I have been reading and learning from here for months!

I was diagnosed with atypical PMR in April 2019, a couple of months after symptoms first appeared, which was a few weeks after getting an infusion of Aclasta (zolodronic acid) for osteoporosis .

I have only found 1 research paper that indicates a connection between the IV infusion of bisphosphonates and long term inflammatory effects , but wonder if anyone else knows of such a connection or developed PMR after treatment with zoledronic acid?

Currently down to 5mg from 20, with the requisite flair ups on the way.

Thanks

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Gotgoat
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PMRpro profile image
PMRproAmbassador

Interesting - haven't heard that before. Could you give the reference please. It is a pig to look for as all they want to tell you is that PMR is treated with steroids and that means the patient needs bisphosphonates!

Gotgoat profile image
Gotgoat in reply toPMRpro

Sure.

pubmed.ncbi.nlm.nih.gov/285...

PMRpro profile image
PMRproAmbassador in reply toGotgoat

Thank you - how very interesting. I think we have had a few in the past with quite bad reactions to bisphosphonate infusions - and of course once you have had it it is there for a long time, you can't just stop taking it!

CT-5012 profile image
CT-5012 in reply toPMRpro

Thank you and to Gotgoat for that information, I was given AA almost twenty years ago which resulted in a major problem with IBS which I still have but not so bad now. I have recently had a crush fracture of a vertebra and several small vertebral fractures. My rheumy suggested, last January, that I have an infusion instead! Hopefully he will have forgotten all about it by the time I next see him, whenever that may be.

Gotgoat profile image
Gotgoat in reply toCT-5012

Good luck!

I take a natural bone formula called Osteoprime ultra made by integrative therapeutics.

CT-5012 profile image
CT-5012 in reply toGotgoat

Thank you, I will have a look at that.

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