Another bend in the journey as I have now been told that I need to start taking Methotrexate. I am feeling upset and weepy at the prospect of more tablets and more horrible side effects and feel overwhelmed with it all. Sorry to be so negative, but this has really knocked me and everything I read about Mtx fills me with dread. Please can anyone out there tell me some good things about it? I am currently on 14mg Pred, can't get below 12 and have been on this journey two and half years. I have already put on masses of weight and my hair is so thin and fragile from previous cancer treatment. It seems that these are two of the side effects I can expect.