Just heard on BBC news that new research justifies some scepticism on the efficacy of bisphosphonates in combating bone decay. Also casts some doubt on the reliability of dexascans for accurate monitoring. Research (from Harwell) was largely focused on osteoporotic patients but should be of interest to all of us who are or have taken these medications as the main finding was that they can cause minute bone fractures over time, something that has been borne out by many posts on this site, particularly in relation to dental treatment which I think was mentioned. All this is from a brief hearing but will try to look up more later on BBC site. Perhaps the more medically qualified among us will already have heard of this.