i am 55. I was diagnosed with PMR after a very rapid onset of excruciating pain in my HANDS. They put me on prednisone and It improved, but not like I've read about others experiences... The inflammation moved all around, like, choosing a joint or joints de jour, if you will. When I finally got into see the rheum. He said I didn't metabolize prednisone properly and changed me to presnilosone, or Medrol at 20 mg. my inflammatory markers responded immediately. I asked about how it presented and he said he had seen that before, that it was not as odd as it seemed to me (hand pain first, the traveling if lammation and pain, etc.) Onset was the first week of Jan. After that, I had a lot of issues that were more the side effects from the steroids than the PMR itself... Primarily sleep disturbance etc. Now I'm at 10 mgs., have been for about a month now... Sleeping much better... Have had almost no pain since starting he Medrol. Tonite sharp pain started in 3 toes of my left foot. Position of foot does not affect it but pain is intense... And then just stops. I've never had a "flare" other than the onset, so I'm unsure of what to be looking for. I felt crappy today, very tired and emotional... This entire experience has been so difficult. I am a registered nurse and held a corporate level position that involved a great deal,of travel and high activity all the time. I feel like I'm being kept in a glass room and I can't see the walls until I hit one and realized I overdid. And I'm not even back to work yet. The fatigue is so intense...and I don't know ANYONE else who has this condition....how do I "learn" limits? What does a flare look like? Is the heightened emotions part of this mess??