It is my understanding that taking prednisone can cause damage to your esophagus when taken on an empty stomach and lying down. Even if it is taken with a few spoons of yogurt does not sound like enough to coat your stomach. I developed gerd and cannot Lie down after eating. I also understand that prednisone can make holes in the lining of your stomach. Just from experience I take a proton pump inhibitor, wait one half hour and eat my breakfast and then take the prednisone. Just a thought for your future intestinal health.