I have now been on 20mgs of Leflunomide for over 6 months. This is supposed to be helping me to reduce the Pred. as I can never get past 10mgs without a flare. I had tapered down to 10mgs but was beginning to feel worse from 11mgs down, and then, after I had to travel and stay for 4 days at a family wedding, I felt absolutely awful ( car journey, stress,hard bed etc.). I realised, (because this has happened to me so often) that I might be going into a flare and so upped the dose back to 11mgs. I decided to stay there as I was going to see Prof. Dasgupta in 2 weeks' time. So, after 2 weeks of doing very little and much pain, I saw him yesterday. I was feeling quite despondent as the Leflunomide didn't seem to have worked, although my ESR has been into the average range for the first time since being on Pred. and my CRP is consistently down but not yet normal. Prof. Dasgupta thought it was worth trying a higher dose ( 30mgs) because of the good blood results and the fact that I am overweight which might mean that I need a higher dose that the average person. This is the first time that my weight has been taken into account and may explain why I have had so much trouble reducing the steroids any lower than I have up till now.
Kate Gilbert mentions bodyweight for dosage in her book, and I just wanted to re-iterate the message- If you are significantly overweight, get the doctors to take this into account when working out the level of drug that you need.
I am hopeful, yet again, that this increase will do the trick and I will be able to reduce the Pred. further within a month or so. I will keep you posted.