I have been on Amitriptyline since the muscle pains began 2.5yr ago. I was on 10mgs for 4 months then increased to 25mgs after that. I am having many disturbed nights due to tongue pain and spasms, I seem to develop discoloured patches and clots on tongue at night. Whilst this is still being investigated 1yr on, my GP suggested increasing my Amitriptyline. When I don't have work the next day I have been taking 50mgs, and find the next day my PMR pains are greatly reduced and the fatigue has lessened. Does anyone else find this with Amitriptyline ? Thursday night I only took 25mgs and suffered all day at work with pains in the shoulders and hips, and exhaustion yesterday. Should also mention I reduced my Pred 10 days ago to 7mgs and muscle pains have been increasing day by day, persevering in case it is Pred withdrawal.