I started to take Methotrexate in May and my levels were: ESR around 20-22 and CRP around 14-17. In July, as the Methotrexate kicked in ( or so I thought) they went down to 16 and 12 respectively. I also stopped most of my work at this point as I kept getting viruses all the time. My last blood test at the end of August showed the levels going up to 21 and 14. During this time, I have been reducing the Pred. from 15mgs to 10mgs, 1mg every fortnight. Today, I am feeling very sore all over and the familiar fatigue that I haven't had since July. Does this mean that the Meth. isn't really doing anything? or that thePMR is flaring? or that the steroid reduction is too fast, too much etc.? Or, should I hold on till my next blood test at the end of this month to see if the results are the same ? I don't really know how significant these results are.