Cholestasis...any one else????: This is what... - PBC Foundation

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Cholestasis...any one else????

amandarosas profile image
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This is what I found under causes of cholestasis......

Within the Liver: Causes include acute hepatitis, alcoholic liver disease, primary biliary cirrhosis with inflammation and scarring of the bile ducts, cirrhosis due to viral hepatitis B or C (also with inflammation and scarring of the bile ducts), drugs, hormonal effects on bile flow during pregnancy (a condition called cholestasis of pregnancy-see see Pregnancy Complicated by Disease: Cholestasis of pregnancy), and cancer that has spread to the liver.

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Magnolia profile image
Magnolia

Cholestasis is caused by obstruction within the liver (intrahepatic) or outside the liver (extrahepatic). The obstruction causes bile salts, the bile pigment bilirubin, and fats (lipids) to accumulate in the blood stream instead of being eliminated normally.

Intrahepatic cholestasis is characterized by widespread blockage of small ducts or by disorders, such as hepatitis, that impair the body's ability to eliminate bile. Extrahepatic cholestasis can occur as a side effect of many medications. It can also occur as a complication of surgery, serious injury, tissue-destroying infection, or intravenous feeding. Extrahepatic cholestasis can be caused by conditions such as tumors and gallstones that block the flow of bile from the gallbladder to the first part of the small intestine (duodenum).

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