Has anyone ever had a positive ANA?
ANA: Has anyone ever had a positive ANA? - PBC Foundation
ANA
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Anyone with PBC most likely has a positive AMA.
Yes. My titer was 1:640. Normal is <1:40
Thanks ... have u been diagnosed with anything else
Not yet but my tests are suggestive of schleroderma & I know without being told I have reynauds. Only in the cold weather do my fingers bother me.
Have you had the ANA Cascade ?
No... just the ANA blood test
Maybe that one is more extensive
Yes it is. It tests for many things. My dr said that’s why they call it “cascade”, 😄. Makes sense. Along with Mitochondrial, my dr ran several others at same time.
The Centromere B antibody test is in the cascade. That one can be suggestive of schleroderma. Yes the tests were extensive & expensive. I think my total lab was just around $800.
R u waiting for results ?
I'm ANA positive with anti centromere antibodies, I do actually have scleroderma as well as PBC, sjogrens, and hypothyroidism. I have at least 6 autoantibodies.
MissusTee...is your schleroderma limited (skin)?
Hi, yes it is limited but I have very little in the way of skin thickening, but my raynauds and gastric issues have been quite bad. Last year I ended up with malnourishment from small intestinal bacterial overgrowth.
Oh my. I’ve had no outward signs. My dr did check for skin tightystound my temple area. All good there. I have noticed if I get a small cut on my hand, it heals but then in that spot the skin is little hard but goes away.
I don't think that would be the type of thickening that they are looking for. In fact the name scleroderma is quite misleading, as a lot of people don't have skin thickening, but it seems to be one of the main things that less experienced doctors look for!
Well I’ve not seen rheumatologist yet. My GI checked skin when I had first visit with him on pbc. I’m not going solely on what he said. I’ve read a lot about schleroderma so I’m aware of the many things it can do. Not good. But some things worse than others. Localized isn’t as destructive as systemic. But neither are good.
I've had two positive ANA tests and 9 of the 11 physical signs of Lupus, yet my doc says I don't have it until she says I do. Grrrr. I doesn't want it but it would be nice to know what is behind my symptoms. My doc and I have a toxic relationship.
I have Positive ANA and AMA M2. Diagnosed with PBC, already had hypothyroid and osteoporosis. In addition, Raynaud’s in cold weather. This summer was a miracle absolutely nothing
78 degrees here today. Came out of grocery store & my middle finger cold & pale😏. Meat market did it. I think my fingers know when the season is changing. I dread winter because of that.
I know. I dread it too. It seemed my feet were always cold even with thick socks. I’d get so frustrated that I would stick my feet in the hottest water I could stand.
I had positive ANA more than 10 years ago during a big flare up of autoimmune connective tissue disease. Interestingly though, it's been negative for many years since (just my AMA is positive now) so ANA status can change.
R u still struggling with connective tissue?
It's at a low level now, thanks for asking. I had intensive therapy with various strong drugs that knocked it back.
How are you feeling?
I got a positive ANA blood test..so I’m a lil freaked out. I’m expecting a call from Hep to see what’s next ... deeper ANA test?
What were u symptoms with connective tissue?
Painful & swollen fingers and general joint pain.
What's bothering you most about the positive ANA?
Well I get pulled tendons and pinched nerves way easier when I’m more active...then that makes my fingers feel tingly ... it goes away after I rest..
The only other thing that I’m getting worried about is pains/soarness around both breasts at various spots. I’m getting an ultrasound done. Doc says could be cystic...
read about ANA blood tests and what they can mean if they are positive. Of course that led me down a rabbit trail of things like
Lupus...Reynolds sjrogrens crest..etc
As of right now I don’t have any of the symptoms but maybe I’m in denial