Just got a call yesterday from my gastroenterologist telling I have preclinical PBC and he set me up with an appointment to discuss treatment. I have a high AMA and briefly had high AST and ALT. Now they are at normal for 1 1/2 yrs, but my AMA is continually going up (now at 75.2 last). This is the first I have heard of preclinical, can anyone tell me what I should expect? I have had other symptoms, but not too severe. Don't know if I want to proceed with treatment after reading some negatives Help please!