ANA test: Hello. I looked at my lab work and... - PBC Foundation

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ANA test

Vera70 profile image
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Hello. I looked at my lab work and noticed that my anti-nuclear antibody pattern is positive but my anti-nuclear antibody (hep2) is negative. How can that be?

My AMA is positive but it's the two ANAs that are different that puzzles me. Does anyone know the difference?

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Vera70 profile image
Vera70
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gwillistexas profile image
gwillistexas

Vera70...I looked back st July test when first diagnosed. ANA Cascade was positive. Pattern-speckled. ANA tiger-1:60(normal 1:40). Centromere B antibody suggested possible scleroderma. Negative on all heps & RA.

gwillistexas profile image
gwillistexas

Supposed to be ANA “titer “. Think I’d better turn off autocorrect.

Phoenixv profile image
Phoenixv

Tell me what ANA test is what does it tell us sorry but I have not heard of this test before thanks

gwillistexas profile image
gwillistexas in reply to Phoenixv

ANA Cascade is a test for other autoimmune diseases.

gwillistexas profile image
gwillistexas in reply to Phoenixv

Phoenix V...also, when my enzymes didn’t come down after 2 weeks off the statin, this is what prompted them to check Mitochondrial M2 & ANA Cascade. If that helps.

Vera70 profile image
Vera70 in reply to Phoenixv

Antinuclear antibodies. It's usually positive in other autoimmune diseases like autoimmune hepatitis which I was first diagnosed with before the PBC from positive AMA.

gwillistexas profile image
gwillistexas in reply to Vera70

Yes, they were all negative for me except possible schleroderma. Just so much to learn about this mess. We’ll figure it out. We have to stay one step ahead🏃🏼‍♀️lol!

Michiganpbc profile image
Michiganpbc

Can you ask the doctor who ordered it? It can mean different things looking at the whole picture there are so many autoimmune diseases that there are hundreds of different tests for I have positive ANA AMA and I was diagnosed with PBC and Sjogrens with sero negative overlap Lupus/Sjogrens. You can have negative test results and still have the disease in some autoimmune diseases that’s why it’s good to ask your doctor for the interpretation. Let us know what they say.

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