wow..a whole community. Im not alone. I was diagnosed about 25 years ago and have been taking urso for the whole time. My elevated enzymes were 600 when i was diagnosed went to down 110 within 6 months...recently rose to 150 but dr doesn't mind. I never knew the itching was part of it and the fatigue! I find it impossible to lose weight no matter what I do or exercise. I dont take prenisdone...wondering if anyone else has this problem?